![]() ![]() There was no significant difference in efficacy between the 2 to younger than 5 year and 5 year and older age groups or by time since vaccination. There were significant differences in the increase in anti-Vi IgG and IgA titres from baseline to day 28 as well as from baseline to 18 months post-vaccination across age groups, with the increse being lowest in the youngest age group. Passive surveillance clinics remained open for the 2-year period until April 9, 2020, providing a full 2 years of follow-up for the primary efficacy endpoint. After being temporarily suspended again on April 28, 2021, owing to a second wave of COVID-19, the study has again resumed from May 27, 2021. Unmasking and vaccination was resumed from Jan 25, 2021. The study participants were informed about the suspension of the vaccination and will be unmasked and offered vaccination after the situation improves and in accordance with government directives. On March 22, 2020, after the government of Nepal's announcement to restrict all unnecessary movement of people owing to the COVID-19 pandemic, the field activities were stopped and unmasking and revaccination could not be completed. Each participant was offered the alternative vaccine to the one they previously received, and a blood sample was taken in a subset of participants. ![]() The unmasking process started from Jan 20, 2020. Follow-up of the trial participants was planned for a 2-year period until the last participant was unmasked. Parents or legal guardians provided written informed consent before enrolment, and assent was sought from children aged 7 years and older. ![]() In this phase 3, double-blind, individually randomised, controlled trial in Lalitpur Metropolitan City, an urban area within Kathmandu Valley, Nepal, we enrolled children aged 9 months to younger than 16 years old. The Lancet Regional Health – Western Pacific.The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology. ![]()
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |